Formulations Built on Patented Science

UC-II® is a patented undenatured Type II collagen that works via oral tolerance — just 40 mg daily has been clinically shown to outperform 1500 mg glucosamine + 1200 mg chondroitin in reducing joint pain and improving mobility. Paired with Mobilee®, a high-molecular-weight hyaluronic acid matrix from rooster comb, this formula restores synovial fluid viscosity and cartilage matrix integrity simultaneously. Glucosamine HCl provides the structural building blocks for glycosaminoglycan synthesis, while Vitamin C acts as an essential cofactor for collagen cross-linking.

Aquamin™ F is a multi-mineral complex derived from the red seaweed Lithothamnion calcareum, providing a naturally occurring matrix of calcium, magnesium and 72 trace minerals — far superior in bioavailability to synthetic calcium carbonate. MenaquinGold® delivers Vitamin K2-7 in its all-trans form, the most bioactive isomer, which activates osteocalcin to direct calcium into bone rather than arterial walls. Plant-sourced Vitamin D3 ensures optimal calcium absorption from the gut, completing a fully evidence-based bone-building triad.

ApresFlex® is a next-generation Boswellia serrata extract standardized for AKBA (acetyl-11-keto-beta-boswellic acid), the most potent anti-inflammatory boswellic acid, clinically shown to reduce joint pain within 5 days. CurcuWIN® uses UltraSOL technology to deliver curcumin with 46x greater bioavailability than standard curcumin, directly inhibiting NF-kB and COX-2 inflammatory pathways. Rosehip extract contributes GOPO (galactolipid) — a natural COX inhibitor — while gingerol provides additional prostaglandin suppression for a multi-target anti-inflammatory effect.

Levagen®+ is a patented liposomal form of Palmitoylethanolamide (PEA), an endogenous lipid mediator that modulates mast cell activity and microglial neuroinflammation — addressing the nerve-pain component of chronic joint conditions that NSAIDs cannot reach. Ubiqsome® CoQ10 uses phytosome technology to deliver ubiquinol directly into mitochondria, restoring ATP production in chondrocytes and synovial cells depleted by oxidative stress. Alpha Lipoic Acid and Trans-Resveratrol further neutralize reactive oxygen species that accelerate cartilage matrix degradation.

Low-molecular-weight sodium hyaluronate is rapidly absorbed orally and shown to accumulate in synovial tissue, restoring the viscoelastic properties of joint fluid that act as both lubricant and shock absorber. N-Acetyl Glucosamine (NAG) is a direct precursor to hyaluronic acid biosynthesis and glycosaminoglycan chains, providing the raw material for continuous synovial fluid replenishment. Chondroitin sulfate inhibits degradative enzymes (MMP-3, MMP-13) that break down the cartilage extracellular matrix, while calcium fructoborate — a naturally occurring boron complex — has been shown to reduce CRP and improve joint comfort within 2 weeks.

Systemic enzyme therapy uses proteolytic enzymes — bromelain from pineapple and papain from papaya — taken on an empty stomach so they are absorbed intact into the bloodstream, where they break down fibrin, immune complexes and pro-inflammatory cytokines rather than digesting food. Rutoside trihydrate (a bioflavonoid) enhances capillary integrity and reduces vascular permeability, directly addressing post-surgical and post-injury oedema. Quercetin dihydrate acts synergistically as a mast cell stabilizer and NF-kB inhibitor, extending the anti-inflammatory duration of the enzyme complex.

Spermidine, a naturally occurring polyamine found in wheat germ, is one of the most studied longevity compounds — it induces autophagy (cellular self-cleaning), reduces osteoclast activity and has been associated with reduced all-cause mortality in population studies. Calcium HMB (beta-hydroxy beta-methylbutyrate) is the most clinically validated anti-catabolic agent for preserving lean muscle mass in sarcopenia, with 3 grams daily shown to reduce muscle protein breakdown by up to 57%. Hydrolyzed collagen peptides provide the specific amino acid sequences (Pro-Hyp, Hyp-Gly) that stimulate osteoblast differentiation and collagen synthesis in bone tissue.

PEA (Palmitoylethanolamide) at 400 mg targets the neuroinflammatory component of radicular pain by downregulating spinal cord microglia and dorsal root ganglion mast cells — the primary drivers of neuropathic pain that conventional analgesics fail to address. Uridine Monophosphate is a rare nucleotide that serves as a direct precursor for myelin sheath synthesis and axonal membrane phospholipids, supporting structural nerve repair in compressed or damaged spinal nerves. Magnesium bisglycinate chelate blocks NMDA receptors in the spinal cord, reducing central sensitization — the mechanism behind chronic, persistent back pain.

Bone mineral density depends not just on calcium but on a precise orchestra of trace elements — zinc activates alkaline phosphatase for bone matrix mineralization, manganese is essential for the synthesis of proteoglycans in cartilage, and copper is required for lysyl oxidase, the enzyme that cross-links collagen and elastin fibers for tensile strength. All minerals are delivered in amino acid chelate form (Albion-style), which bypasses competitive absorption pathways in the gut and achieves 2–4x higher bioavailability than inorganic mineral salts. Molybdenum, often overlooked, is a critical cofactor for sulfite oxidase — an enzyme essential for sulfur amino acid metabolism that directly feeds into cartilage proteoglycan synthesis.

Tendons and ligaments are notoriously slow-healing due to poor vascularity — this formula addresses that limitation by providing mucopolysaccharides (glycosaminoglycans) that form the ground substance of connective tissue extracellular matrix, alongside Type I hydrolyzed collagen peptides that specifically stimulate tenocyte proliferation. Cissus Quadrangularis standardized to 20% ketosterones is the most clinically studied herb for tendon and ligament repair, shown to accelerate healing by 55% compared to placebo in fracture and soft tissue injury trials. Manganese and Vitamin C serve as essential cofactors for prolyl hydroxylase, the enzyme responsible for hydroxylating proline residues in collagen — a critical step for forming the stable triple-helix structure of mature tendon collagen.

Cognizin® Citicoline is the most bioavailable form of choline — it crosses the blood-brain barrier and is hydrolyzed into choline and cytidine, which are then used to synthesize phosphatidylcholine (the primary phospholipid of neuronal membranes) and acetylcholine (the neurotransmitter of memory and attention). Bacognize® is a standardized Bacopa monnieri extract with 45% bacosides, the active saponins shown in 12-week RCTs to significantly improve working memory, information processing speed and reduce anxiety — effects attributed to enhanced dendritic branching in the hippocampus. Suntheanine® L-Theanine promotes alpha-wave brain activity (calm alertness) and synergizes with caffeine-free focus, while Lion's Mane stimulates Nerve Growth Factor (NGF) for long-term neuroplasticity.

Sharp-PS® Green phosphatidylserine is derived from sunflower lecithin (not soy) and is the only nootropic with an FDA-qualified health claim for cognitive dysfunction — it maintains neuronal membrane fluidity, facilitates neurotransmitter release and has been shown in RCTs to improve memory recall in adults with age-associated memory impairment. Alpha GPC provides the most bioavailable form of choline for acetylcholine synthesis, while Huperzine A — a reversible acetylcholinesterase inhibitor — prevents the breakdown of acetylcholine, effectively doubling the cholinergic signal at synapses. Vinpocetine increases cerebral blood flow and ATP production in neurons, while Methylcobalamin B12 is essential for myelin sheath maintenance and homocysteine clearance.

KSM-66® is the world's most clinically studied ashwagandha root extract, with 24 gold-standard RCTs demonstrating significant reductions in serum cortisol (up to 27.9%), perceived stress scores, anxiety and improvements in thyroid function, testosterone and VO2 max. Sensoril® uses a unique root-and-leaf extraction process to deliver a higher concentration of withaferin A and oligosaccharides, providing complementary anti-stress and anti-inflammatory effects to KSM-66®. Rhodiola Rosea standardized to 3% rosavins and 1% salidroside activates the stress-response protein Hsp70 and inhibits COMT enzyme, extending the availability of dopamine and serotonin during periods of acute stress.

Magtein® (Magnesium L-Threonate) is the only form of magnesium clinically proven to cross the blood-brain barrier and increase synaptic magnesium density in the hippocampus and prefrontal cortex — areas that regulate sleep architecture, memory consolidation and anxiety. A landmark MIT study showed Magtein® increased synaptic density by 100% and improved both sleep quality and cognitive performance in aging subjects. Glycine at 3 grams has been shown in Japanese RCTs to reduce core body temperature (a key sleep-onset trigger), improve subjective sleep quality and reduce daytime fatigue — without causing morning grogginess. The ultra-low 0.5 mg melatonin dose is the chronobiologically optimal amount for resetting circadian rhythm without receptor desensitization.

Quatrefolic® delivers 5-methyltetrahydrofolate (5-MTHF) — the biologically active form of folate that bypasses the MTHFR enzyme mutation present in up to 40% of the population, who cannot convert synthetic folic acid into usable folate. This is critical because folate, B12 and B6 work together to convert homocysteine into methionine — elevated homocysteine is an independent risk factor for neurodegeneration, vascular dementia and peripheral neuropathy. Pyridoxal-5-Phosphate (P-5-P) and Riboflavin-5-Phosphate are the active coenzyme forms of B6 and B2 respectively, requiring no hepatic conversion and providing immediate neurological activity — essential for patients with liver dysfunction or malabsorption syndromes.

MenaQ7® delivers Vitamin K2-7 in the 99% all-trans configuration — the only form with demonstrated clinical efficacy in reducing arterial calcification (the Rotterdam Study showed K2 intake inversely correlated with cardiovascular mortality). Ubiquinol is the reduced, electron-rich form of CoQ10 that is directly usable by mitochondria — statin users are particularly deficient as statins block the mevalonate pathway that synthesizes both cholesterol and CoQ10. Bergamot BPF® is a polyphenol fraction from Citrus bergamia with 5 RCTs showing significant reductions in LDL, triglycerides and blood glucose, while Nattokinase (2000 FU) provides fibrinolytic activity — dissolving fibrin clots and reducing blood viscosity without the bleeding risk of pharmaceutical anticoagulants.

Berberine HCl at 97% purity activates AMPK (AMP-activated protein kinase) — the same cellular energy sensor targeted by metformin — reducing hepatic glucose production, improving insulin receptor sensitivity and inhibiting intestinal alpha-glucosidase to slow post-meal glucose absorption. Multiple meta-analyses confirm berberine reduces HbA1c by 0.9% on average, comparable to first-line oral hypoglycemics. Gymnema Sylvestre standardized to 75% gymnemic acids has a unique dual action: gymnemic acids structurally resemble glucose molecules and block intestinal glucose receptors, while simultaneously stimulating pancreatic beta-cell regeneration. Cinnamon bark extract activates insulin receptor tyrosine kinase and inhibits protein tyrosine phosphatase, enhancing insulin signaling at the cellular level.

Re-esterified triglyceride (rTG) omega-3 is the gold standard fish oil form — with 70% greater bioavailability than ethyl ester forms — delivering EPA and DHA in the same molecular configuration as found in fish tissue, ensuring optimal incorporation into cell membrane phospholipids. AstaReal® astaxanthin is a marine carotenoid 6000x more potent than Vitamin C as an antioxidant, specifically protecting omega-3 fatty acids from lipid peroxidation and independently reducing oxidized LDL and inflammatory markers. DeltaGold® tocotrienols (the most bioactive form of Vitamin E) inhibit HMG-CoA reductase — the same enzyme as statins — providing natural cholesterol management, while olive polyphenols (hydroxytyrosol) protect LDL particles from oxidation, the critical step that initiates atherosclerotic plaque formation.

Carnipure® L-Carnitine Tartrate is the pharmaceutical-grade form of L-Carnitine — the essential transporter that shuttles long-chain fatty acids across the inner mitochondrial membrane for beta-oxidation, effectively unlocking stored body fat as an energy source. Without adequate L-Carnitine, fatty acids accumulate in the cytoplasm and cannot be burned. GreenSelect® Phytosome uses lecithin-based phytosome technology to deliver EGCG from green tea with 3x greater bioavailability, inhibiting COMT enzyme to extend norepinephrine-driven thermogenesis. Capsimax® encapsulates capsicum extract in a polymer matrix to deliver the thermogenic benefits of capsaicin without gastric irritation, increasing resting metabolic rate by 4–5% through TRPV1 receptor activation.

Wellmune® is a patented beta-1,3/1,6-glucan derived from baker's yeast, with over 20 published clinical trials demonstrating it primes innate immune cells (neutrophils, macrophages, NK cells) via CR3 receptor binding — significantly reducing upper respiratory tract infection incidence, duration and severity. EpiCor® is a unique fermented yeast metabolite that acts as a postbiotic, modulating both innate and adaptive immunity while simultaneously feeding beneficial gut bacteria — a dual immune-gut axis effect not achievable with standard probiotics. Sambucol® elderberry extract has been shown in 4 RCTs to reduce influenza duration by 4 days and cold duration by 2 days, while PepZin GI® zinc carnosine provides targeted mucosal immune support at the gut lining — the site of 70% of immune activity.

NAD+ (nicotinamide adenine dinucleotide) is the master regulator of cellular energy metabolism and a critical substrate for sirtuins (SIRT1-7) — the longevity enzymes that repair DNA, regulate gene expression and control mitochondrial biogenesis. NAD+ levels decline by approximately 50% between ages 40 and 60, directly correlating with the hallmarks of aging. Uthever® NMN is the most bioavailable NAD+ precursor, with human clinical data showing it raises blood NAD+ levels by 38% within 60 days. Trans-Resveratrol activates SIRT1 and AMPK synergistically with NMN, while Fisetin (Novusetin®) is the most potent senolytic flavonoid identified — selectively clearing senescent ("zombie") cells that drive chronic inflammation and tissue aging.

DE111® is a clinically studied spore-forming Bacillus subtilis strain that survives stomach acid and bile salts with 100% viability — unlike fragile Lactobacillus strains that lose 90% of their potency before reaching the colon. Sunfiber® (partially hydrolyzed guar gum) is the most extensively researched prebiotic fiber, with 75+ clinical studies confirming it selectively feeds Bifidobacterium and Lactobacillus without causing gas or bloating. HMO (Human Milk Oligosaccharide) is a revolutionary prebiotic previously found only in breast milk, now clinically shown to reduce intestinal permeability ("leaky gut"), modulate immune tolerance and improve the gut-brain axis by increasing serotonin-producing enterochromaffin cells. L-Glutamine provides the primary fuel source for enterocytes, repairing tight junction proteins.

Verisol® Bioactive Collagen Peptides are the only collagen ingredient with published RCT data specifically on skin — 2.5 grams daily for 8 weeks was shown to increase skin elasticity by 15%, reduce eye wrinkle depth by 20% and increase dermal collagen density by 12% via stimulation of fibroblast collagen synthesis. AstaReal® astaxanthin at 6 mg provides the most potent photoprotective antioxidant known, neutralizing singlet oxygen (the primary UV-induced reactive species) 550x more effectively than Vitamin E. Ceramosides® wheat ceramides restore the skin's lipid barrier by replenishing ceramide levels in the stratum corneum — the primary determinant of skin hydration and transepidermal water loss. Ester-C® Vitamin C provides 24-hour tissue saturation for continuous collagen hydroxylation.

Testofen® is a patented fenugreek extract standardized to 50% Fenusides — the only fenugreek ingredient with 3 published RCTs showing significant increases in free testosterone (by 98.7% in one trial), sexual function scores and lean body mass in men. It works by inhibiting aromatase (which converts testosterone to estrogen) and sex hormone-binding globulin (SHBG), increasing the bioavailable fraction of testosterone. KSM-66® ashwagandha independently raises testosterone by 15–17% through LH stimulation and cortisol reduction, while PrimaVie® Shilajit — a fulvic acid-rich mineral pitch from the Himalayas — has been shown to increase total testosterone by 23.5% and free testosterone by 19.6% in a 90-day RCT, attributed to its mitochondrial CoQ10 transport and gonadotropin-stimulating fulvic acid content.

Vitex Agnus-Castus (Chasteberry) standardized to 0.5% agnusides acts on dopamine D2 receptors in the pituitary to reduce excess prolactin — elevated prolactin is a primary driver of luteal phase defects, irregular cycles and PMS symptoms. DIM (Diindolylmethane), derived from cruciferous vegetables, shifts estrogen metabolism from the harmful 16-alpha-hydroxyestrone pathway toward the protective 2-hydroxyestrone pathway, effectively reducing estrogen dominance without blocking estrogen entirely. The Myo-Inositol to D-Chiro-Inositol ratio of 40:1 mirrors the physiological plasma ratio and is the most clinically validated nutritional intervention for PCOS — restoring ovarian insulin sensitivity, reducing androgen levels and improving menstrual regularity in over 15 RCTs.

Pycnogenol® (French Maritime Pine Bark) is one of the most comprehensively studied natural compounds for menopause, with a dedicated RCT showing significant reductions in hot flush frequency, night sweats, mood disturbances and sexual dysfunction after 8 weeks — attributed to its ability to modulate serotonin and dopamine receptors and improve microcirculation. Novasoy® soy isoflavones provide phytoestrogens (genistein and daidzein) that bind to estrogen receptor-beta with selective tissue effects — providing estrogenic benefits in bone, brain and cardiovascular tissue without stimulating breast or uterine tissue. Sage leaf extract standardized for rosmarinic acid has been shown in 2 RCTs to reduce hot flush frequency by 64% within 4 weeks, while Black Cohosh acts on serotonergic and opioid receptors to reduce vasomotor symptoms.

Quatrefolic® 5-MTHF is the essential active folate form for neural tube development — critically important for women with MTHFR mutations who cannot activate synthetic folic acid, and for all women as it is immediately bioavailable without hepatic conversion. Myo-Inositol at 4000 mg is the highest-evidence nutritional intervention for improving oocyte quality in PCOS and poor ovarian responders — it reduces FSH requirements in IVF cycles, improves fertilization rates and embryo quality by restoring mitochondrial function in oocytes. CoQ10 Ubiquinol at 200 mg is the most important preconception supplement for egg quality: mitochondria in oocytes require massive ATP output for meiotic spindle formation, and CoQ10 levels in follicular fluid directly correlate with embryo quality and IVF success rates.